Norfloxacin Lactate
China [CN] Norfloxacin, also known as Pipemidic acid or MK-0366, has CAS No. 70458-96-7 and EINECS No. 274-614-4, with molecular formula C₁₆H₁₈FN₃O₃ and molecular weight of 319.33. It is a white to pale yellow crystalline powder with a melting point of 220°C, predicted boiling point 555.8±50.0°C and estimated density of 1.2504. This compound exhibits two dissociation constants at pKa1=6.34 and pKa2=8.75 under 25°C; it is slightly soluble in water, sparingly soluble in 96% ethanol and acetone, while readily soluble in acetic acid, acetone and chloroform. It is hygroscopic and light-sensitive, requiring dry, sealed storage in dark surroundings at room temperature, cataloged as Merck 14,6700. As a classic third-generation fluoroquinolone broad-spectrum antibacterial agent targeting bacterial DNA gyrase, it serves as core pharmaceutical raw material for clinical testing, veterinary antibacterial formulations, laboratory reference standard and organic synthesis intermediate for quinolone derivative research.
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