Glucagon is a prescription hormone used to treat severe hypoglycemia (very low blood sugar) in people with diabetes when they cannot eat or are unconscious. It works by signaling the liver to release stored glucose into the bloodstream, rapidly raising blood sugar levels. It is available as an injectable solution (given into muscle, under the skin, or into a vein) or as a nasal powder (sprayed into one nostril). Common side effects include nausea, vomiting, headache, and injection site reactions.