Quick Detail
Place of Origin
Brand Name
Jinlan
HS-CODE
-
Package & Delivery Lead Time
Package
1g,10g,20g,
Detailed Description
Description
Nerandomilast is a first‑in‑class, oral, selective phosphodiesterase 4B (PDE4B) inhibitor with ≥9‑fold selectivity for PDE4B over other PDE4 isoforms (A/C/D). It elevates intracellular cAMP levels, suppressing pro‑inflammatory cytokine production and fibrotic signaling, thereby reducing lung inflammation and fibrosis.
Approved Indications
- Idiopathic Pulmonary Fibrosis (IPF) in adults
- Progressive Pulmonary Fibrosis (PPF) in adults
Key Features
- First‑in‑class PDE4B‑selective inhibitor for pulmonary fibrosis
- Oral administration (9 mg or 18 mg twice daily)
- Potent anti‑inflammatory and anti‑fibrotic activity
- Favorable safety profile with lower GI side effects vs non‑selective PDE4 inhibitors
- Slows lung function decline in IPF/PPF patients
Applications
API, intermediates, reference standards for R&D, generic registration, and commercial manufacturing.
China [CN] 
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