Resmetirom is an oral, liver-directed, selective THR-β agonist.It reduces hepatic steatosis, inflammation, and fibrosis by selectively activating thyroid hormone receptor-β in hepatocytes,improving lipid metabolism and reducing liver fat.
Approved Indications
Non-cirrhotic non-alcoholic steatohepatitis (NASH) with liver fibrosis
Used to improve metabolic and liver histologic endpoints
Key Features
First-in-class oral selective THR‑β agonist
Liver-targeted, minimal systemic effects
Reduces liver fat, inflammation, and fibrosis
Once-daily oral dosing
Favorable safety profile
Applications
API, intermediates, reference standards for R&D, generic registration and commercial manufacturing.
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