fisetin Folium Cotini Extract

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fisetin Folium Cotini Extract Cotinus coggygria Scop fisetin Folium Cotini Extract Cotinus coggygria Scop We have previously shown that, a flavonol, inhibits IL-4 and IL-13 synthesis by allergen- or anti-IgE-antibody-stimulated basophils. This time, we investigated the inhibition of IL-4 and IL-13 production by basophils by other flavonoids and attempted to determine the fundamental structure of flavonoids related to inhibition. We additionally investigated whether flavonoids suppress leukotriene C4 synthesis by basophils and IL-4 synthesis by T cells in response to anti-CD3 antibody. Methods: Highly purified peripheral basophils were stimulated for 12 h with anti-IgE antibody alone or anti-IgE antibody plus IL-3 in the presence of various concentrations of 18 different kinds of flavones and flavonols. IL-4 and IL-13 concentrations in the supernatants were then measured. Leukotriene C4 synthesis was also measured after basophils were stimulated for 1 h in the presence of flavonoids. Regarding the inhibitory activity of flavonoids on IL-4 synthesis by T cells, peripheral blood mononuclear cells were cultured with flavonoids in anti-CD3-antibody-bound plates for 2 days. Results: Luteolin, fisetin and apigenin were found to be the strongest inhibitors of both IL-4 and IL-13 production by basophils but did not affect leukotriene C4 synthesis. At higher concentrations, these flavonoids suppressed IL-4 production by T cells. Based on a hierarchy of inhibitory activity, the basic structure for IL-4 inhibition by basophils was determined. Conclusions: Due to the inhibitory activity of flavonoids on IL-4 and IL-13 synthesis, it can be expected that the intake of flavonoids, depending on the quantity and quality, may ameliorate allergic symptoms or prevent the onset of allergic diseases. Our hot produts: Grape Skin Extract 98% Resveratrol Grape Skin Extract 50% Resveratrol Grape Skin Extract 5% Resveratrol Polygonum Cuspidatum Extract 98% Resveratrol Polygonum Cuspidatum Extract 50% Resveratrol Emodin 98% Chlorogenic acid 98% Sesamin 98% ursolic acid 98% corosolic acid 1% corosolic acid 10% corosolic acid 20% corosolic acid 98% Bilberry Extract 25% Anthocyanidins Magnolol 90% Honokiol 90% arctiin 40% Chrysin 99% Osthole 90% SHIKIMIC ACID 98% Synepherin 98% Luo Han Guo Extract 90% Mogrosides If you have any further questions or need a sample ,please do not hesitate to contact with me. Wish you all of the best and regards! Sincerely yours, Ms.Jessica Yang Sales Manager Organic Herb Inc. Phone:+86-731-82967870 Mobile:+86-158-74869971 +86-158-74250704 Fax:+86 -731 -82967861 Email: jessica@organic-herb.com Skype:jessicayang22 MSN:yangfangsk@hotmail.com Website: http://www.organic-herb.com

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Changsha Organic-herb Inc

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