Relugolix

China [CN]

Physicochemical Properties

Parameter | Data

Appearance | White to off-white crystalline powder

Solubility | Slightly soluble in water, readily soluble in DMSO and methanol, soluble in ethanol

Dissociation Constant (pKa) | 7.8 (basic nitrogen atom), 4.2 (carboxylic acid group)

Melting Point | 185-188℃ (decomposition)

Stability | Stable for 36 months at 25℃/60% RH, stored in a sealed, cool, and dry place; stable under acidic conditions, easily degraded under alkaline conditions

Chiral Characteristics | Contains one chiral center (pyrrolidine ring C atom), with a single R configuration, optical purity >99.5%

Partition Coefficient (logP) | 4.5 (predicted value)

BCS Classification | Class II (high permeability, low solubility)