Revefenacin

China [CN]

Physicochemical Properties

Parameter | Data

Appearance | Colorless to pale yellow clear solution

Solubility | Good water solubility; the formulation contains sodium chloride, citric acid, and sodium citrate to adjust osmotic pressure and pH.

Dissociation Constant (pKa) | Tertiary amine group pKa ≈ 9.0, weakly alkaline

Partition Coefficient (logP) | 4.2 (predicted value, moderately lipophilic)

Stability | Stable for 24 months at 25℃/60% RH, stored in a sealed, cool, and dry place; the solution is stable for 24 hours after nebulization.

Lung Specificity | The quaternary ammonium salt structure makes it difficult to cross the blood-brain barrier, resulting in low systemic absorption and high concentration in lung tissue.

Plasma Protein Binding Rate | >90% (mainly binds to albumin)