I. Basic InformationItem DetailsEnglish Name VericiguatChinese Name 维立西呱 (Weiliciguat)Chemical Name Methyl {4,6-diamino-2-[5-fluoro-1-[(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}ca…
I. Basic InformationItem | DetailsEnglish Full Name | Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)Chinese Name | 5-[…
Basic InformationItem | DetailsEnglish Name | Fezolinetant; Veozah (Trade Name)Chinese Name | FezolinetantCAS Number | 1229705-11-1Chemical Name | (4-Fluorophenyl)[(8R)-8-methyl-3-(3-methyl-1,2,4-thia…
Physicochemical Properties (Sodium Salt)Appearance: White to off-white/pale yellow powder;Solubility: Easily soluble in water (approximately 100 mg/mL, pH 7.0), soluble in methanol and ethanol, slight…
Core Mechanism of Action and ResistanceMechanism of ActionIt specifically binds to the catalytic core of HIV integrase, inhibiting the strand transfer reaction (a key step in HIV replication), prevent…
Mechanism of Action and ResistanceMechanism: Inhibits the strand transfer reaction of HIV integrase, preventing viral DNA integration into the host genome and blocking viral replication.Resistance:…
PharmacokineticsAbsorption: Oral bioavailability is approximately 30%, and absorption is not affected by food. The time to reach peak concentration (Tmax) is approximately 2 hours.Distribution: Plasma…
Mechanism of Action and Application PotentialMechanism of Action: By inhibiting bacterial dihydrofolate synthase, it blocks dihydrofolate synthesis, thereby inhibiting bacterial nucleic acid synthesis…
Mechanism of ActionIt potently binds to the AR ligand-binding domain, blocking AR nuclear translocation and DNA binding, inhibiting AR-mediated gene transcription, and reducing androgen signaling path…
Mechanism of Action and Antimicrobial SpectrumMechanism of Action: After oral administration, it is hydrolyzed by esterases into tebipenem, which binds to bacterial penicillin-binding proteins (PBPs)…
Mechanism of ActionIt binds to bacterial penicillin-binding proteins (PBPs), inhibiting peptidoglycan cross-linking in the cell wall, leading to bacterial lysis and death.It is stable against most β-l…
Quality Control Key ParametersDetection Method: High-performance liquid chromatography (HPLC) is used, employing a C18 column (e.g., Inertsil ODS-3, 250×4.6mm, 5μm), with a gradient elution using acet…
Mechanism of ActionDual Mechanism of ActionIt binds with high affinity to penicillin-binding protein 2 (PBP2) in Gram-negative bacteria, inhibiting bacterial cell wall synthesis, inducing spheroplast …
Dear Sir/Madam, (HS 030752)We would like to offer: Baby Octopus (frozen). Species: Octopus Vulgaris (short leg, one skin). Condition: whole cleaned. Average size: 20-40 gram per piece. Packaging: bloc…
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