Elagolix Sodium

China [CN]

Physicochemical Properties (Sodium Salt)

Appearance: White to off-white/pale yellow powder;

Solubility: Easily soluble in water (approximately 100 mg/mL, pH 7.0), soluble in methanol and ethanol, slightly soluble in acetonitrile;

Stability: Stable for 6 months at 25°C/60% RH, store in a sealed, cool, and dry place, avoid high temperature and light;

Chiral Characteristics: Contains 1 chiral center (R-configuration), optical purity >99.5%, which is the active configuration.

Summary

Elagolix sodium is a landmark drug for the treatment of endometriosis pain. It offers convenient oral administration, no stimulatory effects, and flexible dosing, balancing efficacy and safety. Clinicians should select the appropriate dose based on the patient's pain level, bone density, and liver function, strictly control the treatment duration, and strengthen drug interaction management to maximize therapeutic benefits.