Biapenem

China [CN]

Mechanism of Action

It binds to bacterial penicillin-binding proteins (PBPs), inhibiting peptidoglycan cross-linking in the cell wall, leading to bacterial lysis and death.

It is stable against most β-lactamases and renal dehydropeptidase I, and can be administered alone without the need for co-administration with enzyme inhibitors such as cilastatin.

Antibacterial Spectrum and Activity

It has strong antibacterial activity against Gram-positive bacteria (except MRSA), Gram-negative bacteria (including Pseudomonas aeruginosa), and anaerobic bacteria.

Its activity against Pseudomonas aeruginosa is superior to imipenem, its effect on anaerobic bacteria is comparable to imipenem, and its activity against Gram-positive bacteria is slightly less than imipenem.

It is effective against multidrug-resistant bacteria such as ESBL-producing Enterobacteriaceae and Acinetobacter species.

Clinical Applications

Indications: Sepsis, pneumonia, lung abscess, secondary infection of chronic respiratory diseases, refractory cystitis, pyelonephritis, peritonitis, gynecological adnexitis, etc.

Dosage and Administration: Adults: 0.3g twice daily, administered by intravenous infusion over 30-60 minutes. Maximum daily dose is 1.2g.

Dosage Forms: Sterile powder for injection, 150mg and 300mg.