2-Chloromethylbenzimidazole

China [CN]

Appearance and Condition: White to pale yellow crystalline powder at room temperature. White needle-shaped crystals appear at higher purity levels, and the color darkens (e.g., light yellow or light brown) with higher impurity content.

Melting Point: Typical melting point range is 173-177°C (affected by purity, with the melting point of pure products concentrated around 175-176°C. Impurities can lower the melting point or extend the melting range).

Solubility:

Poorly soluble in water (solubility approximately 0.1-0.5 g/L at 25°C);

Soluble in polar organic solvents such as dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF), ethanol, and methanol. Soluble in ethyl acetate and chloroform. Solubility is low in non-polar solvents such as n-hexane and benzene. Stability:

It is relatively stable in solid form and can be stored in a cool, dry place, protected from light, and sealed for over 12 months.

In strong alkaline conditions (such as concentrated NaOH or KOH), the chloromethyl group readily undergoes hydrolysis to form 2-hydroxymethylbenzimidazole.

It is highly reactive with nucleophiles such as amines and thiols, and the chlorine atom is easily replaced by a nucleophilic group (e.g., to form aminomethyl and mercaptomethyl derivatives).