5-isopropyl-1,3,4-thiadiazol-2-amine

China [CN]

Synthesis Method: Thiosemicarbazide can be prepared by reacting thiosemicarbazide with the corresponding aldehyde or ketone under certain conditions, followed by cyclization and other steps. For example, according to relevant research, 5-substituted 2-amino-1,3,4-thiadiazole compounds, including 5-isopropyl-1,3,4-thiadiazole-2-amine, can be synthesized using thiosemicarbazide and isopropylaldehyde as raw materials through an iodine-mediated cyclization reaction. In addition, studies have reported that thiosemicarbazide reacts with carboxylic acids in the presence of polyphosphate esters (PPEs) in a one-pot reaction to produce the corresponding 2-amino-1,3,4-thiadiazole compounds in three steps. This method can also be used to prepare 5-isopropyl-1,3,4-thiadiazole-2-amine.

Application: 5-isopropyl-1,3,4-thiadiazole-2-amine and its derivatives have potential biological activity and have promising applications in the pharmaceutical field. Related studies have shown that 2-amino-1,3,4-thiadiazole compounds possess a variety of biological activities, including antibacterial, antifungal, anti-inflammatory, and anticancer activities. For example, some 5-substituted 2-amino-1,3,4-thiadiazole compounds exhibit antibacterial activity against bacteria such as Enterococcus faecalis and methicillin-resistant Staphylococcus aureus, and antifungal activity against fungi such as Candida albicans and Aspergillus niger. Some compounds also exhibit high cytotoxicity against the liver cancer cell line HepG2.