4-Thiazolecarboxylic acid

China [CN]

Physical and Chemical Properties

Appearance and Form: Colorless solid.

Melting Point: 195-199°C.

Solubility: Insoluble in water.

Synthesis

Reaction in ethylene glycol dimethyl ether produces thioformamide, which then reacts with a halogenated pyruvate to produce thiazole-4-carboxylic acid methyl ester, which is further hydrolyzed to produce 4-thiazolecarboxylic acid.

Uses: 4-thiazolecarboxylic acid can be used as a pharmaceutical and pesticide intermediate and as a reagent in organic synthesis. For example, thiabendazole can be prepared by condensing 4-thiazolecarboxylic acid or its ester derivatives with o-phenylenediamine, typically using polyphosphoric acid as a dehydrating agent.