2-Aminothiazol-4-acetic acid

China [CN]

I. Basic Information

Chinese Name: 2-Aminothiazol-4-acetic acid

English Name: 2-Aminothiazol-4-acetic acid

CAS Number: 29676-71-9

Molecular Formula: C₅H₆N₂O₂S

Molecular Weight: 158.18 (Calculated: C 37.96%, H 3.83%, N 17.71%, O 20.23%, S 20.27%)

II. Chemical Structure and Characteristics

Structural Analysis: The molecule is centered around a thiazole ring (a five-membered heterocycle containing sulfur and nitrogen). The 2-position of the thiazole ring is connected to an amino group (-NH₂) and the 4-position is connected to an acetic acid group (-CH₂COOH).

Functional Groups:

Amino group (-NH₂) at position 2: Nucleophilic, capable of participating in reactions such as acylation and diazotization;

Carboxyl group (-COOH) at position 4: Acidic (pKa approximately 2.5-3.5, slightly enhanced by conjugation with heterocycles), capable of salt formation and esterification with bases;

Thiazole ring: An aromatic heterocycle with high stability. The sulfur and nitrogen atoms can bind to metal ions through coordination.