Niraparib toluenesulfonic acid monohydrate is the toluenesulfonic acid salt and hydrated form of niraparib. It is also a selective inhibitor of PARP1/2 (IC50 = 3.8 nM and 2.1 nM) and has been approved…
Sorafenib (trade name Dorgime) is a new drug of molecular targeted therapy. It is an oral multi-target and multi-kinase inhibitor that can target serine/threonine kinases and receptor tyrosine kinases…
Lenalidomide is an immunomodulatory drug. This drug has multiple mechanisms of action. In vitro studies have shown that lenalidomide has three main functions :1) direct anti-tumor effect 2) inhibition…
Breast cancer and ovarian cancer are serious public health problems that seriously threaten women. However, in recent years, the growth rate of breast cancer incidence in China has been 1-2 percentage…
A white or grayish-white non-hygroscopic crystalline solid with a melting point of 195-196℃, it is readily soluble in DMSO and acetonitrile, slightly soluble in anhydrous ethanol, and insoluble in wat…
Abiraterone acetate was initially developed through a collaboration between Cancer Research UK and BTG. Later, the global development rights and marketing rights were transferred to Cougar Biopharmace…
Axitinib (axitinib) is a multi-target small molecule inhibitor, with its main targets being VEGFR, Kit, PDGFR, and RET. The currently approved indication for marketing is the second-line treatment of …
Pazopanib is a novel oral angiogenesis inhibitor developed by GlaxoSmithKline that can interfere with the formation of new blood vessels necessary for the survival and growth of stubborn tumors. It ta…
Ettelavir belongs to 4-quinolone-3-glyoxyacid antiretroviral drugs. It is an HIV integrase inhibitor that can inhibit the transfer of viral DNA strands by HIV integrase, thereby affecting viral replic…
Bikexostat is an HIV protease inhibitor and has been administered in combination with low-dose ritonavir as a drug enhancer, significantly increasing its plasma concentration.
Bicitravir (BIC) is a second-generation integrated enzyme chain transfer inhibitor (INSTI), which has been approved for fixed-dose combination with entracitabine and tenofovir (Alafenamic Chemical Boo…
Lamivudine is a new type of antiviral drug, belonging to nucleoside reverse transcriptase inhibitors. It has a strong inhibitory effect on hepatitis B virus (HBV) in vitro and in experimentally infect…
Derenavir is a new non-peptide antiretroviral protease inhibitor for the treatment of AIDS. It was first successfully developed by Tibotec, the Icelandic branch of Johnson & Johnson Pharmaceu…
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