British Minger

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The name of the British Minger English name Imigran Western drug category Pharmacological action of a white to off-white tablet capsule type, double-convex film while suppressing "GLAXO", the other side there are "IMIGRAN" words. Injection containing 6 mg base amber isotonic salt solution. The drug is a selective 5 - HT 1 receptor agonists on 5 - HT 2 and 5 - HT 3 receptor had no effect. These 5 - HT 1 most of the existence of blood vessels in the brain, the animal experiments found that the drug selectively carotid artery contraction, but it will not change the cerebral blood flow. Injection dynamics bioavailability of the drug as high as 96%, peak blood concentration after the injection after 25 minutes. 6 mg subcutaneous injection of the average peak blood concentration of 72 μg / mL, half-life of 2 hr. Tablets of the drug rapidly after oral absorption, peak blood concentration after 45 minutes. Oral 100 mg, the average peak blood concentration of 54 μg / mL. Mean absolute oral bioavailability of 14%, plasma protein binding rate of 14-21% and the average volume of distribution 170 L, the average total plasma clearance rate is about 1.16 L / min, with an average rate of renal clearance 260 mL / min. Non-renal clearance rate of the total clearance rate of 80%, mainly through the metabolism of the drug excretion. major metabolites for indole acetic acid analogues, mainly through urine excretion, in order to free acid and conjugated glucuronic acid complex there. None of these metabolites of 5-HT1 and 5-HT2 role. 10-15 minutes after subcutaneous injection and oral administration of about 30 minutes after the emergence of clinical response. Indication for migraine and cluster headache attack.

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Wuhan Yuancheng Technology Development Co., Ltd.

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