10-Hydroxycamptothecin

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10-Hydroxycamptothecin
Posting date : Dec 26, 2007
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CAS #: 19685-09-7 Molecular formula:C20H16N2O5 Molucular weight:364.36 Formulation: light yellow white crystalline powder Purity: 98% 10-hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate (a tree native to mainland China). is a kind of pharmaceutical intermediate, an alkaloid originally isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase Ⅰ (Topo Ⅰ)[1]and has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELC[2]and HL-60[3]cells. The purpose of this study is to investigate the proliferation-inhibiting and differentiation-inducing actions of HCPT on human hepatoma Hep G2 cells.

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