brensocatib

AZD7986, also known as Brensocatib, CS-2785 and INS-1007, bears CAS registry number 1802148-05-5 with molecular formula C₂₃H₂₄N₄O₄. Its full stereochemical systematic name is (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide. This chiral compound is a pale yellow to yellow solid, demonstrating high solubility in DMSO up to 100.0 mg/mL (237.83 mM) for cell-based pharmacological assays. Long-term storage at -20 °C is required to retain chemical stability, with its structural identifiers including InChIKey and SMILES string provided for synthetic, chromatographic and analytical laboratory reference. Functionally, Brensocatib (AZD7986) acts as a potent dipeptidyl peptidase 1 (DPP1) inhibitor, with species-specific pIC50 values of 6.85 (human), 7.6 (mouse), 7.7 (rat), 7.8 (dog) and 7.8 (rabbit). It is extensively used as a core research reagent for preclinical studies of inflammatory signaling, neutrophil serine protease regulation and inflammatory disease mechanisms, and is available as solid powder as well as pre-formulated 10 mM DMSO stock solution for in vitro biochemical and cellular testing.