Sepiapterin
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China [CN] L-Sepiapterin, also known as Sepiapterin, carries CAS registry number 17094-01-8 with molecular formula C₉H₁₁N₅O₃ and molecular weight of 237.22. Its full stereochemical systematic name is (S)-2-amino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one, and it is also available as dihydrate form with ≥99% purity grade. This chiral compound exists as a sticky yellow solid, decomposing above 270 °C upon heating, with a predicted boiling point of 448.1±55.0 °C and a predicted density of 1.86±0.1 g/cm³. It dissolves in DMSO at 27 mg/mL for biochemical assays, requires long-term storage at -20 °C, and is light-sensitive so light exposure must be avoided during handling and preservation. Functionally, L-Sepiapterin acts as a critical natural cofactor of nitric oxide synthase (NOS), widely used as a core biochemical research reagent to study tetrahydrobiopterin biosynthesis, nitric oxide signaling pathways, enzymatic cofactor activity and related metabolic disease mechanisms in cell-free and cell-based in vitro laboratory experiments.
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