sebetralstat

KVD900, also named Sebetralstat, bears CAS registry number 1933514-13-6 with molecular formula C₂₆H₂₆FN₅O₄ and molecular weight 491.51. Its full systematic chemical name is N-[(3-fluoro-4-methoxy-2-pyridinyl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxo-1(2H)-pyridinyl)methyl]phenyl]methyl]-1H-pyrazole-4-carboxamide. This compound is a white to off-white solid, featuring a predicted boiling point of 762.3±60.0 °C and a predicted density of 1.29±0.1 g/cm³. It exhibits excellent solubility in DMSO at ≥125 mg/mL (254.32 mM), which facilitates cell-based biological assays. Long-term storage at -20 °C is required to maintain chemical stability, with its InChIKey and SMILES structural codes provided for synthetic, chromatographic and analytical reference. Functionally, Sebetralstat (KVD900) acts as a potent plasma kallikrein inhibitor documented in patent WO2016083820, widely deployed as a core laboratory research reagent for investigating plasma kallikrein signaling pathways and conducting preclinical studies on metabolic disorders. It is supplied as solid powder as well as pre-formulated 10 mM DMSO stock solution for in vitro pharmacological testing.