Atrasentan Hydrochloride
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China [CN] Atrasentan hydrochloride, also known as research code ABT-627 and Abbott 147627, has CAS registry number 195733-43-8, with the molecular formula C₂₉H₃₈N₂O₆·HCl and molecular weight of 547.08. Its full stereochemical systematic name is (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid monohydrochloride. This chiral compound appears as an off-white to grey powder, freely soluble in DMSO for cell-based biological testing. Strict storage requirements demand preservation at 2–8 °C under inert nitrogen or argon atmosphere to prevent degradation, with structural identifiers InChIKey and SMILES string available for analytical and synthetic reference. Functionally, Atrasentan hydrochloride is a selective endothelin A (ETA) receptor antagonist widely utilized for preclinical research on pulmonary hypertension, renal disease and cardiovascular signaling pathways. It is supplied as solid powder as well as pre-made 10 mM DMSO stock solution to support in vitro pharmacological assays and mechanism-of-action investigations.
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