Mirdametinib

PD 0325901, CAS No. 391210-10-9, is a potent selective MEK 1/2 inhibitor with the molecular formula C₁₆H₁₄F₃IN₂O₄ and a molecular weight of 482.19. Its full systematic chemical name is (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide. This chiral compound exists as an off-white to white solid with a melting point ranging from 112–114 °C, a predicted density of 1.817±0.06 g/cm³, and an optical rotation of [α]/D -1.8 to -3.5° (c = 1 mg/mL in methanol). It dissolves clearly in DMSO at a concentration of 20 mg/mL, demonstrating good solubility for cell-based biological assays. For storage, solid PD 0325901 should be kept at 2–8 °C, while its DMSO or ethanol stock solutions remain stable for up to 3 months when stored at -20 °C. Widely used in in vitro and in vivo research targeting the MAPK/ERK signaling pathway, this compound serves as a core research tool to study MEK-mediated cell proliferation, tumor progression and related oncogenic mechanisms, and is available as solid powder or sterile-filtered 10 mM DMSO solution for laboratory pharmaceutical and cancer biology investigations.