dulaglutide

Dulaglutide (trade name: Trulicity) is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. It consists of two identical, disulfide-linked chains, each containing a modified human GLP-1 analog covalently linked to a modified human immunoglobulin G4 (IgG4) Fc fragment to extend its duration of action. By activating GLP-1 receptors, it stimulates glucose-dependent insulin secretion, suppresses inappropriate glucagon secretion, and slows gastric emptying. Due to its engineered structure, it is resistant to degradation by the enzyme DPP-4 and has an extended half-life of approximately 4.7 to 5 days, allowing for once-weekly subcutaneous administration