Liraglutide
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China [CN] Liraglutide is a transparent and colorless solution. The dosage form is subcutaneous injection. Liraglutide, after more than 10 years of research and development, has numerous functions such as promoting the regeneration of pancreatic islet cells, lowering blood sugar, reducing weight and protecting the cardiovascular system. Its trade name is Victoza, which is used to treat type 2 diabetes, and its trade name is Saxenda, which is used to treat chronic obesity. It serves as a supplement to diet control and physical exercise. Liraglutide is an acylated human glucagon-like peptide-1 (GLP-1) receptor agonist, sharing 97% amino acid sequence homology with human endogenous GChemical Book LP-1 (7-37), retaining all the biological activities of GLP-1, and having a GLP-1 receptor agonist effect. Through the expression of recombinant DNA in Saccharomyces cerevisiae, its molecular structure differs from that of the natural GLP-1 molecule by only one amino acid. The structure only modifies GLP-1 in the following two parts: the 34th lysine is replaced by arginine, and a glutamate-mediated 16-carbon palmitoyl fatty acid side chain is added to the 26th lysine.
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