Tirzepatide
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China [CN] tirzepatide is a novel glucagon-like peptide-1 receptor (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP, also known as gastric inhibitory polypeptide) dual-receptor pathway agonist, administered once a week. Both GLP-1 and GIP belong to incretin, which are polypeptides secreted by the mucous membranes of the human gastrointestinal tract. The former can bind to receptors on pancreatic islet cells and stimulate insulin secretion, thereby exerting a hypoglycemic effect. It can also delay gastric emptying and suppress appetite, thus controlling weight. The latter has functions such as inhibiting the secretion of gastric acid and pepsin, stimulating insulin release, suppressing gastric peristalsis and emptying, and can supplement the effect of GLP-1 receptor agonists. tirzepatide integrates the effects of two insulin-stimulating drugs into a single molecule, representing a new class of drugs for the treatment of type 2 diabetes.
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