Ethyl 3,3-dibromo-2-oxopropanoate

Basic information:

CAS No.: 76179-25-4

Molecular formula: C₅H₆Br₂O₃

Molecular weight: 273.91g/mol

Physical and chemical properties:

Appearance and properties: Usually a colorless liquid with a pungent odor.

Solubility: Soluble in common organic solvents, insoluble in water.

Synthesis method: It can be prepared by reacting propionic acid with bromine in the presence of a base such as sodium hydroxide. The reaction is carried out at room temperature and the product is separated by fractionation. It can also be synthesized by multi-step reactions of ethyl acetoacetate, reacting with bromine, sodium hydroxide, hydrochloric acid, etc. in sequence, and finally treating with sodium carbonate to obtain the target product.

Uses: It is an important organic synthesis intermediate, which can be used to prepare drugs (such as antiviral and antitumor compounds) and pesticide intermediates, and introduce other functional groups through the substitution reaction of bromine atoms; it can also be used to synthesize α-ketoester derivatives to construct heterocyclic compounds such as pyrrole and furan; it can also be used as an acylating agent or carbon chain building block in the synthesis of natural products, and can also be used for organic reaction mechanism research, such as nucleophilic substitution, debromination reaction and other experiments.

Safety information: It has certain toxicity. If it is not handled properly, it may cause harm to the human body. When using it, you should pay attention to protection, avoid contact with skin and eyes, and prevent inhalation of its vapor.