(1S,2S)-cyclopentane-1,2-diol

Basic information

Chinese name: (1S,2S)-Cyclopentane-1,2-diol

English name: (1S,2S)-Cyclopentane-1,2-diol

CAS number: 3234-45-3 (Note: Please note the difference in CAS numbers of isomers)

Molecular formula: C₅H₁₀O₂

Molecular weight: 102.13 g/mol

Stereochemistry: Chiral compound with two adjacent hydroxyl groups (1,2-diol structure), configuration (1S,2S), enantiomer with (1R,2R), and mesomorph with (1R,2S).

Physical and chemical properties

Appearance: Usually white crystalline solid or colorless viscous liquid, the specific form is related to purity and temperature.

Melting point: about 46-48℃ (different literature may vary slightly).

Boiling point: about 224-226℃ (normal pressure), or distilled under reduced pressure (such as 120℃/15 mmHg).

Density: about 1.12 g/cm³ (25℃).

Solubility: easily soluble in polar solvents such as water, methanol, ethanol, acetone, and slightly soluble in non-polar solvents such as ether.

Chiral characteristics: optically active, with a specific rotation [α]ₙ²⁰ of about - 40° (soluble in ethanol, the specific value needs to be adjusted according to the measurement conditions).

Uses

Organic synthesis intermediates:

As chiral building blocks, used to prepare optically active drugs or natural products, such as antiviral drugs, anti-tumor compounds, etc.

Used to synthesize chiral ligands (such as ligands for asymmetric catalytic reactions), or as chiral auxiliary agents to participate in stereoselective synthesis.

Materials Science:

It can be used as a monomer for polymer materials such as polyesters and polyurethanes, or used to prepare functional coating materials.

Research reagents:

As a standard in chiral chemistry research or to verify the stereoselectivity of asymmetric synthetic reactions.