Pharmaceutical Grade API Daprodustat CAS 960539-70-2

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Product
Pharmaceutical Grade API Daprodustat CAS 960539-70-2
Posting date : May 18, 2023
Membership
Free Member Scince May 09, 2023
FOB Price
$1000/kg
Min. Order Quantity
1kg
Supply Abillity
500kg
Port
Qingdao
Payment Terms
TT,LC
Package
5kg/drum
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Contact
Melissa wang
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
Loncom
HS-CODE
-
Package & Delivery Lead Time
Package
5kg/drum
Detailed Description

Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK. Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces erythropoiesis. A phase 3 clinical trial (NCT02879305) found that in patients with CKD undergoing dialysis, daprodustat was non-inferior to erythropoiesis-stimulating agents regarding the change in the hemoglobin level from baseline and cardiovascular outcomes.

In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia.On October 2022, the FDA Cardiovascular and Renal Drugs Advisory Committee (CRDAC) supported that the benefit of treatment with daprodustat outweighs the risks for adult dialysis patients with anemia of CKD but not for non-dialysis patients with anemia of CKD.7 On February 1, 2023, daprodustat was fully approved by the FDA as the


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