Procaine HCL cas51-05-8
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China [CN] At room temperature, procaine hydrochloride is a fine white needle-like crystal or crystalline powder, odorless, slightly bitter and tingling, easily soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether.In the structure of procaine hydrochloride, the ester bond can be hydrolyzed to form p-aminobenzoic acid and diethylaminoethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to form toxic aniline.The structure of procaine hydrochloride has aromatic amino group, which is easy to oxidize and change color. The oxidation and change color can be accelerated by pH value, temperature, ultraviolet light, oxygen and metal ions.
Hydrochloric acid procaine is a local anesthetic, can temporarily block the conduction of nerve fibers and has an anesthetic effect, strong effect, low toxicity, and no addiction, but on the skin, mucous membrane penetration is weak, not suitable for surface anesthesia, clinical mainly used for infiltration, spine and conduction anesthesia.
The aqueous solution of this product is stable in pH3.0 ~ 5.0.Therefore, when preparing procaine hydrochloride injection, it is generally necessary to add acid to adjust pH3.3 ~ 5.5, and strictly control the sterilization temperature and time. It is advisable to circulate steam for sterilization at 100℃ for 30min, and attention should be paid to shading and airtight preservation.This product structure of the aromatic amino in dilute hydrochloric acid, with sodium nitrite to generate diazo salt, coupled with basic β-naphthol reaction, the generation of scarlet azo compounds.
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