Methylated DNA Quantification Kit (Fluorometric)

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Product
Methylated DNA Quantification Kit (Fluorometric)
Posting date : Dec 21, 2017
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Free Member Scince Jan 12, 2015
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1
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1
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1
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1
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1
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1
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Candy Ton
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Product Detail
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Place of Origin
United States [US]
Brand Name
Creative BioMart
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1
Detailed Description
DNA methylation occurs by the covalent addition of a methyl group at the 5-carbon of the cytosine ring by DNA methyltransferases, resulting in 5-methylcytosine (5-mC). In somatic cells, 5-mC is found almost exclusively in the context of paired symmetrical methylation of the dinucleotide CpG, whereas in embryonic stem (ES) cells, a substantial amount of 5-mC is also observed in non-CpG contexts. The biological importance of 5-mC as a major epigenetic modification in phenotype and gene expression has been recognized widely. For example, decrease in 5-mC content (DNA hypomethylation) is likely caused by methyl-deficiency due to a variety of environmental influences, and has been proposed as a molecular marker in multiple biological processes such as cancer. It has been well demonstrated that the decrease in DNA methylation is one of the most important characteristics of cancer. Thus, the quantification of 5-mC content or methylation in cancer cells could provide very useful information for detection and analysis of this disease.
https://www.creativebiomart.net/methylated-dna-quantification-kit-fluorometric-463321.htm

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