Damnacanthal CAS No477-84-9

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Product
Damnacanthal CAS No477-84-9
Posting date : Nov 04, 2016
Membership
Free Member Scince Nov 04, 2016
FOB Price
95USD/MG
Min. Order Quantity
100mg
Supply Abillity
500kgs per month
Port
SHENZHEN
Payment Terms
TT or L/C
Package
1MG/bottle
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
Dieckmann
HS-CODE
2804-10
Package & Delivery Lead Time
Package
1MG/bottle
Delivery Lead Time
within 5 days after payment confirmed in our bank
Detailed Description
Damnacanthal CAS No477-84-9
Detailed Information:
Name
3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
CAS NO
477-84-9
Synonym
Damnacanthal
Molecular Weight
282.34
M.F:
C16H10O5
Purity
98%min
Appearance
Orange-yellow solid
Place of origin
China
Solubility
Soluble to 25 mM in DMSO
Certificate
SGS
Documents available
COA,MSDS,NMR, HPLC
Packing
1Kg/bag
25Kg/Drum
Shelf life
2 years
Storage
-20 °C, sealed, avoid light,in N2
 
 
Description:
Damnacanthal is an anthraquinone which acts as a p56lck tyrosine kinase inhibitor. It can be extracted from Morinda citrifolia.  have long been used in traditional medicine for the treatment of cancer .  
Name
3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
Synonym
Damnacanthal
Assay
≥ 98%min
CAS
477-84-9
Molecular formula:
C16H10O5
Percentage Composition:
C 68.09%; H 3.57%; O 28.34%
Melting Point:
Mp 218-218.5℃
Physical Description:
Orange-yellow solid
Biological Source
extracted from Morinda citrifolia.
primary target 
p56lck autophosphorylation
primary target IC50  
17 nM against p56lck autophosphorylation
Packaging:
Packaged under inert gas
Storage
-20 °C, sealed, avoid light,in N2
Usage
A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase
The period of validity
2 years
 
Overview
A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase activity. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck over PKA and PKC and >40 fold selectivity for p56lck over EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56lck over pp60src and pp59fyn. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype of ras-transformed cells.
 
Application:
It have long been used in traditional medicine for the treatment of cancer .
 
Features :
1.Any inquiries will be replied within 12 hours.2. Dedication to quality, supply & service.3. Strictly on selecting raw materials.4. OEM/ODM Available.5. Reasonable & competitive price, fast lead time.6. Sample is available for your evaluation & Formulation development.7. Faster delivery:Sample order in stock and 3-7 days for bulk production.8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.9. After-Sale Service:(1) International Authorized Third-Party Test For The Products You Demand.
 
Contact :
If you have any further questions or need a sample,Please do not hesitate to contact us.
 
ShenZhen Dieckmann Technology Development Co., LTDShenZhen Address:2floor,3 building, Maluan Make Place,2-10south of Jinlong Road, Pingshan New district,ShenzhenZip code: 518172Tel: 86-755-89213952Fax: 86-755-84813563Email: sale@dkmchem.com

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