Pharmacokinetic In Vitro Assays

  Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai Government. 

Available studies include:

• Method development and validation (GLP & Non-GLP) 
• Bioanalysis 
• Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies,  Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB  penetration ) 
• Stability in vehicles and plasma 
• Drug interaction studies
• In vitro metabolic stability
• Prediction and identification of major metabolites
• Toxicokinetics analysis
• Distribution studies 

Pharmacokinetics Package for IND Filing

DMPK package for CFDA and FDA IND filing

• Chemical Compounds
• Traditional Chinese Medicine
• Protein
• Antibody

Metabolic Stability Services

• CYP Reaction Phenotyping
• Microsomal Stability
• S9 Stability
• Hepatocyte Stability
• Plasma Stability
• Metabolite Profiling & Identification

Drug-Drug Interaction Services

• Cytochrome P450 and UGT Reaction Phenotyping
• Hepatocyte Induction
• Cytochrome P450 Inhibition
• Time Dependent Inhibition (Single Point)

Permeability and Transporter Services

• Caco-2 Permeability
• P-gp Inhibition

Available reaction phenotyping services include:

• Phase I:
• Cytochrome P450 Enzymes (CYP)

• Phase II:
• UDP-glucuronyltransferases (UGT)

Metabolic Stability

• Microsomes stability
• Hepatocytes stability
• Plasma stability
• S9 stability

Protein Binding Services

• Plasma Protein Binding
• Brain Tissue Binding
• Whole Blood Binding
• Blood to Plasma Ratio