naldemedine tosylate

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Selling leads
naldemedine tosylate
Posting date : Jun 23, 2026
Membership
Free Member Scince Jun 22, 2026
FOB Price
1
Min. Order Quantity
10g
Supply Abillity
50000kgs
Port
Beijing
Payment Terms
100% TT in Advance
Package
1
Keyword :
API
Category
Contact
Winnie Wang
Selling Leads Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
JINLAN Brand
Model Number
1345728-04-2
HS-CODE
-
Package & Delivery Lead Time
Package
1
Delivery Lead Time
7-14
Detailed Description
Naldemedine Tosylate, also known as p-toluenesulfonate salt of Naldemedine or S-297995 tosylate, has CAS No. 1345728-04-2, molecular formula C₃₂H₃₄N₄O₆·C₇H₈O₃S and molecular weight of 742.84. It is an orally active peripherally acting mu-opioid receptor antagonist (PAMORA).
This off-white to pale yellow solid demonstrates potent high binding affinity and antagonistic activity against recombinant human μ-, δ-, and κ-opioid receptors, with Ki values of 0.34 nM, 0.43 nM, 0.94 nM and IC50 values of 25.57 nM, 7.09 nM, 16.1 nM respectively. It is primarily applied in preclinical research on opioid-induced constipation (OIC). Additionally, computational studies predict it can bind to 3CLpro protease encoded by SARS-CoV-2 genome, supporting antiviral mechanism exploration. Supplied as research-grade solid reagent, it serves as a core tool compound for opioid receptor pharmacology, gastrointestinal disorder drug discovery and coronavirus protease inhibitor screening.

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