tradipitant

China [CN]

Tradipitant, also known by research codes VLY-686 and LY686017, carries CAS registry number 622370-35-8 with molecular formula C₂₈H₁₆ClF₆N₅O and molecular weight of 587.9. Its full systematic chemical name is 2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinylmethanone. This compound exists as a pale beige to brown solid with a melting point range of 143–145 °C, predicted boiling point of 640.9±65.0 °C and predicted density of 1.45±0.1 g/cm³. It is sparingly soluble in chloroform and ethyl acetate, and classified as hygroscopic, requiring strict storage at -20 °C under inert nitrogen or argon atmosphere to prevent moisture degradation. Complete structural identifiers including InChIKey and SMILES string are available for synthetic, chromatographic and analytical laboratory reference. Functionally, Tradipitant acts as a selective neurokinin 1 (NK-1) receptor antagonist, widely applied as a core preclinical research reagent for studying neurokinin signaling, neurological disorders, pain regulation and neuropsychiatric disease mechanisms. It is supplied as solid powder as well as pre-formulated 10 mM DMSO stock solution for in vitro neuropharmacology and cellular functional assays.