aficamten

China [CN]

Aficamten, also known by research codes CK-274, CK-3773274 and E1016, has CAS registry number 2364554-48-1 with molecular formula C₁₈H₁₉N₅O₂ and molecular weight of 337.38. Its full stereochemical systematic name is (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide. This chiral compound exists as white to light brown crystalline solid with a predicted density of 1.40±0.1 g/cm³. It dissolves in DMSO up to 125 mg/mL (370.50 mM, sonication required for complete dissolution), with predicted pKa value of 13.84±0.20; full structural identifiers including InChI, InChIKey and SMILES string are provided for synthetic and analytical lab reference. Functionally, Aficamten is a novel cardiac myosin inhibitor with an IC50 value of 1.4 μM, widely utilized as a core preclinical research reagent for investigating hypertrophic cardiomyopathy (HCM), cardiac muscle contraction mechanisms and cardiovascular disease signaling pathways. This reagent is supplied as crystalline solid powder as well as pre-formulated 10 mM DMSO stock solution for in vitro cardiomyocyte and cardiovascular pharmacological assays.