ziftomenib
China [CN] Ziftomenib, also designated research code KO-539, bears CAS registry number 2134675-36-6 with molecular formula C₃₃H₄₂F₃N₉O₂S₂ and molecular weight of 717.87. Its full stereochemical systematic name is (S)-4-methyl-5-((4-((2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)propyl)-1H-indole-2-carbonitrile. This chiral compound appears as a light brown to brown solid, with a predicted boiling point of 851.4±75.0 °C and a predicted density of 1.44±0.1 g/cm³. Long-term storage at -20 °C is required to preserve chemical stability, with predicted pKa value of 8.03±0.10 for reference in biochemical buffer setup. As a targeted small-molecule kinase inhibitor, Ziftomenib is widely utilized as a core preclinical research reagent for investigating oncogenic signaling pathways, hematological malignancies and tumor proliferation mechanisms, supplied as solid powder and pre-formulated 10 mM DMSO stock solution for in vitro cellular and pharmacological laboratory assays.
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