paltusotine
China [CN] Paltusotine, designated research code CRN00808, has CAS registry number 2172870-89-0 with molecular formula C₂₇H₂₂F₂N₄O and molecular weight of 456.49. Its full systematic chemical name is 3-(4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl)-2-hydroxybenzonitrile. This compound exists as a white-to-yellow solid, featuring a predicted boiling point of 640.4±55.0 °C and a predicted density of 1.41±0.1 g/cm³. It is slightly soluble in DMSO at a concentration range of 0.1–1 mg/mL. Complete structural identifiers including InChI, InChIKey and SMILES string are provided for synthetic, chromatographic and analytical laboratory reference. Functionally, Paltusotine is an orally bioavailable, non-peptide selective somatostatin subtype 2 (SST2) receptor agonist. It holds potential to sustain stable GH and IGF-1 levels after long-acting somatostatin receptor ligand intervention, making it a core research reagent for preclinical investigations into acromegaly and neuroendocrine tumor pathogenesis, hormone signaling and related endocrine disorder mechanisms.
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