CAS No.: 195148-06-1
Molecular Formula: C₂₁H₂₀ClN₅O₃S | Molecular Weight: 457.94
Dosage Form: 50mg Tablet | Manufacturer: Zelgen Pharmaceuticals (Suzhou), China
Product Overview
A China-developed first-class innovative drug, Jaktinib Hydrochloride is an oral multi-target inhibitor (JAK1/2/3/TYK2 + ACVR1) with independent IP, mainly used for hematological tumors and autoimmune diseases.
Mechanism of Action
• Inhibits JAK-STAT pathway to suppress abnormal immunity and cell proliferation, targeting JAK2 V617F (core mutation of myelofibrosis).
• Unique ACVR1 inhibition improves iron metabolism, increases hemoglobin and reduces transfusion dependence in myelofibrosis patients.
China [CN] 
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