Sarolaner

China [CN]

Core Specifications

• Chemical Name: 1-[5'-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]spiro[azetidine-3,1'(3'H)-isobenzofuran]-1-yl]-2-(methylsulfonyl)ethanone
• Formula: C₂₃H₁₈Cl₂F₄N₂O₅S | Molecular Weight: 581.36
• Appearance: White to off-white crystalline powder
• Purity: ≥98.0% (HPLC) | Storage: Room temperature, dry, sealed

Key Features

• High potency: 3–4× more active than afoxolaner against fleas/ticks
• Long-lasting: 30 days protection with a single oral dose
• Rapid onset: Kills fleas in 8 hours, ticks in 12 hours post-administration
• Broad-spectrum: Effective against fleas, ticks, mites, and lice
• Palatable: Formulated as beef-flavored chewables (Simparica®) for dogs

Main Applications (Dogs ≥8 weeks, ≥1.3kg)

• Flea control: Treat/prevent Ctenocephalides felis; break flea life cycle
• Tick control: Ixodes scapularis, Dermacentor variabilis, Rhipicephalus sanguineus, Amblyomma americanum, Haemaphysalis longicornis
• Mange treatment: Sarcoptic and demodectic mange (off-label)
• Disease prevention: Reduces transmission of tick-borne diseases (Lyme, ehrlichiosis)
• Combination use: Key component of Simparica Trio (with moxidectin + pyrantel) for heartworm + internal parasite control