Sacubitril Valsartan | Global Trade leader ecrobot

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Sacubitril Valsartan

Posting date : Feb 25, 2026

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Membership

Free Member Scince Jul 07, 2025

FOB Price

$314.5

Min. Order Quantity

10g

Supply Abillity

Stock

Port

Ningbo

Payment Terms

T/T 100%

Package

1g,10g,20g,

Keyword :

chemical

Category

Contact

Lunar

Selling Leads Detail

Company Info

Quick Detail

Place of Origin

China [CN]

Brand Name

Jinlan

HS-CODE

Package & Delivery Lead Time

Package

1g,10g,20g,

Detailed Description

CAS No.：936623-27-4

Molecular Formulas:

Sacubitril: C₂₄H₂₉NO₅
Valsartan: C₂₄H₂₉N₅O₃

Molecular Weight: 1294.50 (sodium salt complex)

Characteristic

Appearance: White to off-white powder
Solubility: Slightly soluble in water, soluble in methanol, DMSO
Storage: Sealed, dry, protected from light

Pharmacological Category

First-in-class angiotensin receptor neprilysin inhibitor (ARNI)

Antihypertensive / heart failure agent

Mechanism of Action

Sacubitril: Neprilysin inhibitor → increases natriuretic peptides
Valsartan: Angiotensin II AT₁ receptor antagonist
Dual action: vasodilation, natriuresis, diuresis, antifibrotic, antihypertensive

Indications

Chronic heart failure (HFrEF) to reduce cardiovascular death and hospitalization
Hypertension

Key Features

Oral, once or twice daily
Superior to ACEI/ARB in reducing heart failure outcomes
Balances neurohormonal activation

Main Adverse Reactions

Hypotension
Hyperkalemia
Renal impairment
Cough (less than ACEI)
Angioedema (rare)

Contraindications

Hypersensitivity to sacubitril, valsartan, or excipients
History of angioedema with ACEI/ARB
Concomitant ACEI (washout period required)
Severe hepatic impairment
Pregnancy