Tazobactam Sodium

China [CN]

Tazobactam Sodium: Key Information

Generic Name: Tazobactam Sodium  Chinese Name: 他唑巴坦钠  CAS Number: 89785-84-2  Molecular Formula: C₁₀H₁₁N₄NaO₅S  Molecular Weight: 322.27 g/mol  Chemical Name: (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4,4a,5,6,7,7a-hexahydro-1H-pyrrolo[2,1-c][1,3]thiazine-2-carboxylic acid sodium salt

Drug Type and Mechanism of Action

Drug Type: β-lactamase inhibitor (sodium salt form)

Mechanism of Action:

Irreversibly inhibits various β-lactamases (penicillinases, cephalosporinases, and some extended-spectrum β-lactamases)

Protects co-administered antibiotics from hydrolysis, restoring antibacterial activity against resistant bacteria

Weak antibacterial activity on its own; must be used in combination with penicillins/cephalosporins

Core Clinical Applications

Classic Combination: Piperacillin-Tazobactam Sodium

Indications:

Moderate to severe mixed infections (respiratory tract, abdominal cavity, urinary tract, sepsis, skin and soft tissue)

Infections caused by β-lactamase-producing resistant bacteria (E. coli, Klebsiella, Staphylococcus, etc.)

Clinical Ratio: Commonly 8:1 (Piperacillin:Tazobactam)

Physicochemical Properties (API)

Appearance: White to off-white crystalline powder

Solubility: Very soluble in water, easily soluble in methanol, slightly soluble in ethanol

Stability: Aqueous solution is slightly alkaline; requires protection from light, airtight sealing, and dry storage

Chirality: Multiple chiral centers, single isomer