Tazobactam

China [CN]

Tazobactam Core Information

Generic Name: Tazobactam  Chinese Name: 他唑巴坦  CAS Number: 89786-84-5  Molecular Formula: C₁₀H₁₂N₄O₅S  Molecular Weight: 300.29 g/mol  Chemical Name: (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4,4a,5,6,7,7a-hexahydro-1H-pyrrolo[2,1-c][1,3]thiazine-2-carboxylic acid

Drug Type and Mechanism of Action

Drug Type: β-lactamase inhibitor

Mechanism of Action:

Irreversibly binds to and inhibits various β-lactamases (including penicillinases, cephalosporinases, and some metalloenzymes)

Protects co-administered antibiotics from hydrolysis, restoring activity against resistant bacteria

Has very weak antibacterial activity on its own and must be used in combination with penicillins/cephalosporins

Core Clinical Applications

Classic Combination: Piperacillin-Tazobactam

Indications:

Moderate to severe mixed infections (respiratory tract, abdominal cavity, urinary tract, sepsis, skin and soft tissue)

Infections caused by β-lactamase-producing resistant bacteria (E. coli, Klebsiella, Staphylococcus, etc.)

Ratio: Clinically commonly used 8:1 (Piperacillin:Tazobactam)

Physicochemical Properties (API)

Appearance: White to off-white crystalline powder

Solubility: Easily soluble in water, methanol, and ethanol

Storage: Sealed, dry, protected from light, stable at room temperature

Chirality: Multiple chiral centers, single isomer