3-FLUOROAZETIDINE HYDROCHLORIDE

China [CN]

Melting Point: 178~182℃ (decomposition)  Capillary method (GB/T 617, precise temperature control ±1℃)

Boiling Point: / (Hydrochloride is a solid, decomposes at high temperature, free base boiling point ≈65℃) /

Solubility: Easily soluble in water, methanol, ethanol, dichloromethane; slightly soluble in ethyl acetate, acetone; insoluble in n-hexane, toluene, diethyl ether  Visual method + gravimetric method (25℃)

Moisture Content: ≤0.5% (industrial grade) / ≤0.3% (pharmaceutical grade) Karl Fischer titration method (coulometric method)

Dissociation Constant (pKa): ~9.5 (cyclic amino group, 25℃ aqueous solution) Potentiometric titration method

Density: 1.28±0.02 g/cm³ (25℃) Pycnometer method

Stability: Stable under normal temperature, dry and sealed storage; avoid high temperature (>180℃), strong alkalis, strong oxidizing agents; dehydrochlorination under alkaline conditions produces free base (volatile, easily oxidized) Accelerated test (40℃/75% RH, 14 days)

Hygroscopicity: Slightly hygroscopic (25℃/80% RH, weight gain ≤0.5%) Dynamic vapor sorption (DVS)

Flash Point: / (Non-flammable solid) /