3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE

China [CN]

Melting Point: 185~189℃ (decomposition)  Capillary method (GB/T 617)

Boiling Point: / (Hydrochloride is a solid, decomposes at high temperature) /

Solubility: Easily soluble in water, methanol, ethanol, dichloromethane; slightly soluble in ethyl acetate, acetone; insoluble in n-hexane, toluene  Visual method + Gravimetric method

Moisture Content: ≤0.5% (industrial grade) / ≤0.3% (pharmaceutical grade) Karl Fischer titration (coulometric method)

Dissociation Constant (pKa): ~9.2 (cyclobutylamine amino group, 25℃ aqueous solution) Potentiometric titration

Density: 1.32±0.02 g/cm³ (25℃) Pycnometer method

Stability: Stable under normal temperature, dry and sealed storage; avoid high temperature (>190℃), strong oxidizing agents, and strong alkaline environments (will dehydrochlorinate to form free amine) Accelerated test (40℃/75% RH, 14 days)

Hygroscopicity: Slightly hygroscopic (25℃/80% RH, weight gain ≤0.5%) Dynamic moisture adsorption method