1-Methyl-cyclopropanesulfonic acid amide

China [CN]

Physical State: At room temperature, it is a white to off-white crystalline powder, odorless, and non-hygroscopic (weak hydrogen bonding of the sulfonamide group, no special moisture protection required);

Melting Point: 108~112℃ (melting range ≤4℃; a melting range exceeding this indicates the presence of raw materials/sulfonylation byproducts), a key indicator for identification and initial purity assessment;

Solubility: Easily soluble in water (solubility at 25℃ ≈ 35g/L), easily soluble in methanol, ethanol, acetone, DMF, DMSO, slightly soluble in ethyl acetate, dichloromethane, insoluble in n-hexane, petroleum ether, toluene (polarity characteristics suitable for aqueous/organic phase reactions);

Dissociation Constant: pKa ≈ 10.2 (sulfonamide N-H, weakly acidic), aqueous solution is nearly neutral (pH 6.5~7.5), reacts with bases to form sulfonamide salts (such as sodium salt, potassium salt, further increasing solubility);

Stability:

Stable for ≥24 months when stored dry and sealed at room temperature (25℃), without degradation;

Stable to heat (≤150℃), acid (pH 2~7), and base (pH 7~12), only cyclopropane ring opening occurs at high temperatures (>200℃), without sulfonamide group decomposition;

Avoid contact with strong oxidizing agents (such as potassium permanganate, potassium dichromate) to prevent the sulfonamide group from being oxidized to sulfonyl oxide.