Tofogliflozin Intermediates/E

China [CN]

Molecular Formula: C18H40O7Si4

Molecular Weight: 480.34 (exact value, calculated using standard atomic weights of elements)

Chiral Centers: C3, C4, C5, and C6 are all chiral carbons, with fixed configurations of 3R, 4S, 5R, 6R, consistent with the chiral configuration of natural D-glucose.

Core Structure: The tetrahydropyran-2-one ring is the parent structure, with the hydroxyl groups at positions 3, 4, 5, and the hydroxymethyl group at position 6 all substituted with trimethylsiloxy (-OTMS) groups. It is a typical hydroxyl-protected sugar lactone.

Predicted Physical Properties (based on structural characteristics):

State: Colorless oily liquid or white crystalline solid at room temperature (silylated derivatives are often low-melting solids/oils with excellent solubility);

Solubility: Easily soluble in non-polar organic solvents (n-hexane, dichloromethane, toluene), moderately soluble in medium-polarity solvents (ethyl acetate, tetrahydrofuran), insoluble in water (siloxane bonds are easily hydrolyzed in water, requiring anhydrous storage conditions);

Stability: Sensitive to acids and bases, should be stored at low temperature under an anhydrous inert gas (N₂/Ar) atmosphere.  Exposure to water/alcohols will remove the TMS protecting groups, generating gluconolactone.