1-(4-((2R,5R)-2,5-bis(4-chloro-2-fluoro-5-nitrophenyl)pyrrolidin-1-yl)-2,6-difluorophenyl)-4-(4-fluorophenyl)piperidine

China [CN]

1. Appearance: Pale yellow to yellow crystalline powder (contains dinitroaromatic rings; high nitro content leads to coloration, and the higher the purity, the lighter the color); 2. Solubility: Slightly soluble in water, readily soluble in dichloromethane, tetrahydrofuran, N,N-dimethylformamide (DMF), and toluene, soluble in ethyl acetate, and sparingly soluble in methanol/petroleum ether (due to multiple halogen atoms + nitro groups + aromatic rings, it is highly lipophilic); 3. Stability: Stable under sealed, vacuum, and light-protected storage at room temperature (recommended ≤25℃), avoid strong reducing agents (nitro groups can be reduced), high temperatures (≥100℃ can cause dehalogenation of the aromatic ring), and strong light (nitroaromatic rings are prone to photodegradation); it has good tolerance to weak acids/bases; 4. Melting point: Expected 160~180℃ (chiral pyrrolidine + polyhalogenated aromatic ring + heterocycle, moderate melting point, can be used as an auxiliary indicator for purity assessment).