(2S,2'S)-[[(2R, 5R)-1-[3,5-difluoro-4-(4-(4- fluorophenyl)-1-piperidinyl)phenyl]-2,5-pyrrolidinediyl]bis[6-fluoro-2-(2S)-2-pyrrolidinyl 1H-benzimidzol e-2,5-diyl)]bis(1-pyrrolidinecarboxylic acid, 1,1'-bis(1,1'-dimethylethyl)ester

China [CN]

1. Appearance: White to off-white crystalline powder (typical form of a highly complex chiral heterocyclic ester intermediate; higher purity results in better crystallinity); 2. Solubility: Slightly soluble in water, readily soluble in dichloromethane, tetrahydrofuran, and N,N-dimethylformamide (DMF), soluble in ethyl acetate, sparingly soluble in methanol/petroleum ether (highly lipophilic due to multiple fluorine substitutions and multiple heterocyclic rings); 3. Stability: Stable under sealed vacuum storage at room temperature in the dark (recommended ≤20℃), avoid strong acids (Boc deprotection), strong bases (benzimidazole ring opening), high temperatures (easily decomposes at ≥100℃), and strong light (fluorinated aryl groups are prone to photolysis); 4. Melting point: Expected 200~220℃ (high melting point due to multiple chiral centers, multiple heterocyclic rings, and aryl groups).