SOTA-008

China [CN]

Molecular Weight: 394.85 (for molar concentration calculations and quantitative analysis)

Core Structural Features: 1. Chiral center: (5S) configuration, L-xylopyranose core, non-natural configuration, highly customizable; 2. Substituents: C-arylation modification at the 5-position (C-C bond connection, more resistant to enzymatic hydrolysis than O-glycosidic bonds, improving drug stability in vivo), aryl group contains chlorine atom and ethoxybenzyl group, which can adjust molecular lipophilicity and target binding affinity; 3. Hydroxyl group status: Hydroxyl groups at positions 1, 2, 3, and 4 are all free (different from tetraacetylated derivatives, providing more diverse reaction sites).

Key Physicochemical Properties (Inferred): 1. Appearance: White to off-white crystalline powder; 2. Solubility: Slightly soluble in water, readily soluble in methanol, ethanol, dichloromethane, and ethyl acetate, sparingly soluble in petroleum ether; 3. Stability: Stable under sealed storage at room temperature and protected from light, avoid strong acids (glycosidic bond cleavage), strong bases (aryl side chain hydrolysis), and high temperatures (easily degrades at ≥100℃); 4. Melting point: Expected 160~180℃ (free hydroxyl groups + aryl group, higher melting point).

Core Quality Indicators (Suggested): 1. Chiral purity (ee value): ≥99% ((5S) configuration, core indicator, affecting the optical activity of downstream drugs); 2. Chemical purity (HPLC): ≥98.5%; 3. Moisture content: ≤0.5% (carbohydrate derivatives are prone to moisture absorption, strict humidity control is required); 4. Isomer impurities: α/β-pyranose isomers ≤0.5% (xylopyranose ring is prone to conformational isomerism); 5. Residual solvents: Compliant with ICH Q3C (to avoid affecting downstream reactions).