1H-Indole-2-carboxamide, 1-[(1S,2S)-1-[(Z)-amino(hydroxyimino)methyl]-2-methylcyclopropyl]-N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-

China [CN]

Molecular Formula (Derived): C₂₈H₃₄N₄O₃ (Based on C₂₈H₃₁N₃O₂ of M-6, the cyano group (-CN) is replaced by [(Z)-NH₂(NOH)CH-], adding 1 N, 1 O, and 3 H)

Molecular Weight (Derived): 474.60 (Used for molar calculations and product quantification, 33.04 greater than M-6)

Core Use: A key downstream intermediate in the synthesis of the active pharmaceutical ingredient Orforglipron, serving as a core transition intermediate for the conversion of the cyano group to a urea side chain.

Key Structural Features: Contains a (Z)-type double bond isomer, a hydroxylimino group (-NOH), and an amino group (-NH₂), adding hydrogen bond donors/acceptors, affecting solubility and purification processes.

Related Intermediate: Obtained from Orforglipron Intermediate M-6 (CAS: 2212021-81-1) through a cyano-hydroxylamine reaction.